| Name | CR | MR | Type | Environment |
| Demon, Marilith | 21 | 8 | outsider (chaotic, demon, evil, extraplanar, mythic) | any (Abyss) |
| Demon, Nalfeshnee | 17 | 7 | outsider (chaotic, demon, evil, extraplanar, mythic) | any (Abyss) |
| Demon, Vrock | 11 | 4 | outsider (chaotic, demon, evil, extraplanar, mythic) | any (Abyss) |
| Devastator | 22 | 8 | construct (extraplanar, mythic) | any (Abyss) |
| Devil, Bone Devil | 11 | 4 | outsider (devil, evil, extraplanar, lawful, mythic) | any (Hell) |
| Devil, Ice Devil | 16 | 6 | outsider (devil, evil, extraplanar, lawful, mythic) | any (Hell) |
| Dragon (Black), Mature Adult Black Dragon | 15 | 6 | dragon (mythic, water) | warm marshes |
| Dragon (Blue), Mature Adult Blue Dragon | 17 | 7 | dragon (earth, mythic) | warm deserts |
| Dragon (Green), Very Old Green Dragon | 20 | 8 | dragon (air, mythic) | temperate forests |
| Dragon (Red), Wyrm Red Dragon | 25 | 10 | dragon (fire, mythic) | warm mountains |
| Dragon (Red), Young Red Dragon | 12 | 5 | dragon (fire, mythic) | warm mountains |
| Dragon (White), Juvenile White Dragon | 9 | 3 | dragon (cold, mythic) | cold mountains |
| Drakainia | 25 | 10 | aberration (mythic) | any |