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Alternative Means of Relief

Source Horror Adventures pg. 141
Should a curse seem impossible to end by either normal or conditional means, the accursed might take desperate measures for even temporary relief from their suffering. Many such methods are dire enough that creatures may consider them worse than simply being cursed.

Death: Some curses end upon the death of the victim, perhaps leading a victim to take her own life in the hope of being raised from the dead free of the curse. Although some find release this way, others are sorely disappointed; some gods may not smile upon such wanton suicide—or the victims might be restored to life, only to find themselves still afflicted by the curse.

Making Amends: A curse laid as punishment for a misdeed might be neutralized by rectifying the misdeed. But there are no guarantees. Undoing the misdeed and additionally offering a comparable effort to make up for the trouble caused might allow a new saving throw against the curse to remove it. Forgiveness from the curse-layer grants a +4 bonus on this saving throw. For curses that require amends, remove curse generally fails unless and until such amends are made.

Symbiosis: On rare occasions, a character might allow the curse to infect her very being as a desperate attempt to mitigate the effects, hoping that this will give her some measure of control. Symbiosis with a curse is rarely successful, and it usually leads to contracting an accursed corruption, as the curse takes over the creature’s personality. In rare cases, curse symbiosis might transform the accursed into a monster associated with curses (such as a hag) without first going through an accursed corruption.