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Archives of Nethys

Pathfinder RPG (2nd Edition) Pathfinder RPG (1st Edition) Starfinder RPG

Corruptions | Curses | Diseases | Drugs | Haunts | Madnesses | Poisons | Traps

Diseases
NameTypeFortitude SaveOnsetFrequencyEffectCure
Bonecrusher (Dengue)injuryDC 121 week1/day1d4 Dex damage2 consecutive saves
Filth FeverinjuryDC 121d3 days1/day1d3 Dex damage and 1d3 Con damage2 consecutive saves
Fungal FluinhaledDC 123d6 days1/day1d4 Con. Rolling a 1 on any Fortitude save to resist taking damage from fungal flu results in blindness. The blindness persists - even resisting spells like remove blindness/deafness - until the disease is cured.2 consecutive saves
Leprosycontact, inhaled, or injuryDC 12 ((negates; DC 20 to avoid effects))2d4 weeks1/week1d2 Cha damage2 consecutive saves
MindfireinhaledDC 121 day1/day1d4 Int damage2 consecutive saves
Ghoul FeverinjuryDC 131 day1/day1d3 Con and 1d3 Dex damage2 consecutive saves
Green HazecontactDC 131 day1/day-4 on Perception checks, target is permanently blinded if it fails 3 saves2 consecutive saves
ShakescontactDC 131 day1/day1d8 Dex damage2 consecutive saves
Brainwormscontact or injuryDC 141 day1/day1d3 Wis damage and 1d3 Int damage, if damaged in combat, target must make a second Fort save or gain the confused condition for the duration of the encounter2 consecutive saves
Devil ChillsinjuryDC 141d4 days1/day1d4 Str damage3 consecutive saves
Sleeping SicknessinjuryDC 141d2 days1/day1d4 Wis damage and target is fatigued2 consecutive saves or arsenic (see text)
Slimy DoomcontactDC 141 day1/day1d4 Con damage, target must make a second Fort save or 1 point of the damage is drain instead2 consecutive saves
Tetanus injuryDC 141d6 days1/day 1d4 Dex. Each time someone takes Dexterity damage from tetanus, there's a 50% chance his jaw muscles stiffen, preventing speech and the use of spells with verbal components for the next 24 hours. 2 consecutive saves
Glacier Plaguecontact or injuryDC 151 day1/day1d6 points of Dex damage and target is exhausted, its speed is reduced by half, and it is unable to speak2 consecutive saves
GreenscaleinjuryDC 151d6 days1/week1d2 Cha damage and 1d2 Dex damage, target must make a second Fort save or 1 point of the Cha damage is drain instead2 consecutive saves
Moxix's DelectationinjuryDC 151 day1/day1d3 Con and 1d3 Wis damage2 consecutive saves
Red AcheinjuryDC 151d3 days1/day1d6 Str damage2 consecutive saves
Spellscar Feveringested or inhaledDC 15 (+1 per previous save)2d6+1 days1/day1d2 Con damage, 1d2 Cha drain2 consecutive saves
The Tainted PlaguecontactDC 15 (see description)1 day1/day1d6 Con and 1d6 Wis2 consecutive saves
Blinding SicknessingestedDC 161d3 days1/day1d4 Str damage, if more than 2 Str damage, target must make an additional Fort save or be permanently blinded2 consecutive saves
Blood Veilcontact or injuryDC 16 (the first time ethnically Varisian humanoids, including human, half-elves, and half-orcs with Varisian parentage, are exposed to blood veil, each such character has a flat 5% chance that she is immune to the disease)1 day1/day1d4 Con damage and 1d4 Cha damage 
BonechillinjuryDC 161 day1/day1d4 Dex damage and any nonlethal damage incurred from being in a cold environment becomes lethal damage (though it can still cause hypothermia)2 consecutive saves
Boot SoupcontactDC 161 day1/dayspeed reduced by 5 feet and 1d3 Dex damage, creatures reduced to 0 feet are permanently paralyzed2 consecutive saves, or completely skinning or burning the affected area (inflicting 1d8 points of damage)
Cackle FeverinhaledDC 161 day1/day1d6 Wis damage2 consecutive saves
Dvezda Plagueingested or inhaledDC 161d4 days1/day1d4 Con damage and 1 Dex damage2 consecutive saves
Dysentarycontact or injuryDC 161d3 days1/day1d6 nonlethal damage and target is fatigued and staggered2 consecutive saves
Pulsing PuffsinjuryDC 161 day1/day1d4 Dex damage2 consecutive saves
The Scalescontact or injuryDC 161d4 days1/2 days1d2 Dex damage and 1d2 Cha damage2 consecutive saves. Reptiles and creatures with the reptilian subtype receive a -2 penalty on saving throws and require 3 consecutive saves to recover.
Bubonic Plagueinjury or inhaledDC 171 day1/day1d4 Con damage and 1 Cha damage and target is fatigued2 consecutive saves
Chillbane Feverinhaled, injuryDC 171 day1/day1d4 Con damage and target is sickened and fatigued2 consecutive saves
Firegutinjury or inhaledDC 171 day1/daytarget is staggered3 consecutive saves
Demon FeverinjuryDC 181 day1/day1d6 Con damage, target must make a second Fort save or 1 point of the damage is drain instead2 consecutive saves
Demonplagueinjury or ingestedDC 181 day1/day1d3 Con damage and 1d6 Wis damage, and victim is fatigued if it takes any ability damage from the disease; certain creatures slain by demonplague rise as plagued beasts (see page 56)3 consecutive saves
Malaria (Jungle Fever)injuryDC 181d3 days1/day1d3 Str damage and 1d3 Con damage and target is fatigued2 consecutive saves
Red Dripcontact (fungus)DC 181 day1/day1d4 Dex damage and 1d2 Cha damage2 consecutive saves or amputation of infected limb
ErgiacontactDC 201 day1/day1d4 Str damage and 1d4 Con damage, target must make a second Fort save or 1 point of the damage is drain instead, and a creature that has suffered ability drain glows blue as if limned with faerie fire2 consecutive saves
Scarlet LeprosycontactDC 201 day1/day1d6 Con damage and 1d6 Cha damage; whenever the character takes Con damage, 1 point is permanent drain2 consecutive saves
Vorel's Phagecontact or ingestion DC 201 day1/day1d4 Cha and 1d4 Con.2 consecutive saves
Blightburn Sicknesscontact (see text)DC 221 day1/day1d6 Con damage and 1d6 Cha damage; contact is automatic when a creature comes within a 60- foot radius of blightburn, and can be blocked only by lead sheeting, 1 foot of stone, or a force effect2 consecutive saves
Crypt Fevercontact or inhaledDC 221 minute1/day1d6 Str damage, 1d6 Cha damage, and victim is exhaustedcrypt fever can only be cured by successfully casting remove curse and remove disease within 1 minute of each other.
Daemonic WastingcontactDC 231 day1/day1d4 Con damage and 1d4 Cha damage2 consecutive saves